Polymyalgia rheumatica-like syndrome from checkpoint inhibitor therapy: case series and systematic review of the literature
Identifieur interne : 000036 ( France/Analysis ); précédent : 000035; suivant : 000037Polymyalgia rheumatica-like syndrome from checkpoint inhibitor therapy: case series and systematic review of the literature
Auteurs : Cassandra Calabrese [États-Unis] ; Laura C. Cappelli [États-Unis] ; Marie Kostine [France] ; Elizabeth Kirchner [États-Unis] ; Tawnie Braaten [États-Unis] ; Leonard Calabrese [États-Unis]Source :
- RMD Open [ 2056-5933 ] ; 2019.
Abstract
To assess whether the polymyalgia rheumatica (PMR)-like syndrome reported as an immune related adverse event (irAE) from checkpoint inhibitor therapy is consistent with the 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) provisional criteria for PMR.
The cases were derived from two sources. Group 1 represents reported cases from three contributing centres. Group 2 was derived from a systematic review of the literature searching for all cases reported as PMR or PMR-like illness associated with checkpoint inhibitor therapy. Cases were assessed for the quality of reporting and then analysed to determine whether they fulfilled the 2012 EULAR/ACR provisional criteria for PMR.
A total of 49 patients were included for analysis. Among the entire group, 37 (75%) were designated ‘complete’ indicating that they had sufficient data to reliably apply the 2012 EULAR/ACR criteria. 28 (75%) cases fulfilled complete criteria for PMR. A number of cases also demonstrated some clinical features unusual for idiopathic PMR.
This study suggests a high proportion of reported cases of checkpoint inhibitor-related PMR fulfil preliminary criteria for PMR, yet in one quarter clinical details were incomplete making verification problematic. Furthermore, in the absence of a gold standard for the diagnosis of PMR, the relationship of checkpoint inhibitor-related PMR to the idiopathic form remains unclear.
Url:
DOI: 10.1136/rmdopen-2019-000906
PubMed: 31168414
PubMed Central: 6525600
Affiliations:
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Cappelli</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Division of Rheumatology</institution>,<institution>Johns Hopkins School of Medicine</institution>,<addr-line content-type="city">Baltimore</addr-line>,<addr-line content-type="state">Maryland</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kostine, Marie" sort="Kostine, Marie" uniqKey="Kostine M" first="Marie" last="Kostine">Marie Kostine</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Rheumatology Department</institution>,<institution>Centre Hospitalier Universitaire de Bordeaux</institution>,<addr-line content-type="city">Bordeaux</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kirchner, Elizabeth" sort="Kirchner, Elizabeth" uniqKey="Kirchner E" first="Elizabeth" last="Kirchner">Elizabeth Kirchner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Rheumatic & Immunologic Disease</institution>,<institution>Cleveland Clinic</institution>,<addr-line content-type="city">Cleveland</addr-line>,<addr-line content-type="state">Ohio</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Braaten, Tawnie" sort="Braaten, Tawnie" uniqKey="Braaten T" first="Tawnie" last="Braaten">Tawnie Braaten</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Division of Rheumatology</institution>,<institution>Johns Hopkins School of Medicine</institution>,<addr-line content-type="city">Baltimore</addr-line>,<addr-line content-type="state">Maryland</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Calabrese, Leonard" sort="Calabrese, Leonard" uniqKey="Calabrese L" first="Leonard" last="Calabrese">Leonard Calabrese</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Rheumatic & Immunologic Disease</institution>,<institution>Cleveland Clinic</institution>,<addr-line content-type="city">Cleveland</addr-line>,<addr-line content-type="state">Ohio</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">RMD Open</title><idno type="eISSN">2056-5933</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To assess whether the polymyalgia rheumatica (PMR)-like syndrome reported as an immune related adverse event (irAE) from checkpoint inhibitor therapy is consistent with the 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) provisional criteria for PMR.</p></sec><sec><title>Methods</title><p>The cases were derived from two sources. Group 1 represents reported cases from three contributing centres. Group 2 was derived from a systematic review of the literature searching for all cases reported as PMR or PMR-like illness associated with checkpoint inhibitor therapy. Cases were assessed for the quality of reporting and then analysed to determine whether they fulfilled the 2012 EULAR/ACR provisional criteria for PMR.</p></sec><sec><title>Results</title><p>A total of 49 patients were included for analysis. Among the entire group, 37 (75%) were designated ‘complete’ indicating that they had sufficient data to reliably apply the 2012 EULAR/ACR criteria. 28 (75%) cases fulfilled complete criteria for PMR. A number of cases also demonstrated some clinical features unusual for idiopathic PMR.</p></sec><sec><title>Conclusion</title><p>This study suggests a high proportion of reported cases of checkpoint inhibitor-related PMR fulfil preliminary criteria for PMR, yet in one quarter clinical details were incomplete making verification problematic. Furthermore, in the absence of a gold standard for the diagnosis of PMR, the relationship of checkpoint inhibitor-related PMR to the idiopathic form remains unclear.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="June, Ch" uniqKey="June C">CH June</name></author><author><name sortKey="Warshauer, Jt" uniqKey="Warshauer J">JT Warshauer</name></author><author><name sortKey="Bluestone, Ja" uniqKey="Bluestone J">JA Bluestone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cappelli, Lc" uniqKey="Cappelli L">LC Cappelli</name></author><author><name sortKey="Gutierrez, Ak" uniqKey="Gutierrez A">AK Gutierrez</name></author><author><name sortKey="Bingham, Co" uniqKey="Bingham C">CO Bingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suarez Almazor, Me" uniqKey="Suarez Almazor M">ME Suarez-Almazor</name></author><author><name sortKey="Kim, St" uniqKey="Kim S">ST Kim</name></author><author><name sortKey="Abdel Wahab, N" uniqKey="Abdel Wahab N">N Abdel-Wahab</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calabrese, C" uniqKey="Calabrese C">C Calabrese</name></author><author><name sortKey="Kirchner, E" uniqKey="Kirchner E">E Kirchner</name></author><author><name sortKey="Kontzias, K" uniqKey="Kontzias K">K Kontzias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dasgupta, B" uniqKey="Dasgupta B">B Dasgupta</name></author><author><name sortKey="Cimmino, Ma" uniqKey="Cimmino M">MA Cimmino</name></author><author><name sortKey="Maradit Kremers, H" uniqKey="Maradit Kremers H">H Maradit-Kremers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salem, J E" uniqKey="Salem J">J-E Salem</name></author><author><name sortKey="Manouchehri, A" uniqKey="Manouchehri A">A Manouchehri</name></author><author><name sortKey="Moey, M" uniqKey="Moey M">M Moey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cappelli, Lc" uniqKey="Cappelli L">LC Cappelli</name></author><author><name sortKey="Gutierrez, Ak" uniqKey="Gutierrez A">AK Gutierrez</name></author><author><name sortKey="Baer, An" uniqKey="Baer A">AN Baer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Mh" uniqKey="Smith M">MH Smith</name></author><author><name sortKey="Bass, Ar" uniqKey="Bass A">AR Bass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, St" uniqKey="Kim S">ST Kim</name></author><author><name sortKey="Tayer, J" uniqKey="Tayer J">J Tayer</name></author><author><name sortKey="Trinh, Va" uniqKey="Trinh V">VA Trinh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stroud, Cr" uniqKey="Stroud C">CR Stroud</name></author><author><name sortKey="Hedge, A" uniqKey="Hedge A">A Hedge</name></author><author><name sortKey="Cherry, C" uniqKey="Cherry C">C Cherry</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Calabrese, Cassandra" sort="Calabrese, Cassandra" uniqKey="Calabrese C" first="Cassandra" last="Calabrese">Cassandra Calabrese</name></noRegion><name sortKey="Braaten, Tawnie" sort="Braaten, Tawnie" uniqKey="Braaten T" first="Tawnie" last="Braaten">Tawnie Braaten</name><name sortKey="Calabrese, Leonard" sort="Calabrese, Leonard" uniqKey="Calabrese L" first="Leonard" last="Calabrese">Leonard Calabrese</name><name sortKey="Cappelli, Laura C" sort="Cappelli, Laura C" uniqKey="Cappelli L" first="Laura C" last="Cappelli">Laura C. Cappelli</name><name sortKey="Kirchner, Elizabeth" sort="Kirchner, Elizabeth" uniqKey="Kirchner E" first="Elizabeth" last="Kirchner">Elizabeth Kirchner</name></country><country name="France"><noRegion><name sortKey="Kostine, Marie" sort="Kostine, Marie" uniqKey="Kostine M" first="Marie" last="Kostine">Marie Kostine</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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